By William W. Cohen

This functional advisor presents a succinct remedy of the overall innovations of mobile biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.

The e-book explores 3 varied aspects of biology: biological platforms, experimental methods, and language and nomenclature. After a short advent to phone biology, the textual content specializes in the rules in the back of the most-widely used experimental methods and mechanisms, touching on them to well-understood innovations in machine technological know-how.

The presentation of the cloth has been ready for the reader’s speedy take hold of of the subject: reviews on nomenclature and heritage notes will be ascertained at a look, and crucial vocabulary is boldfaced through the textual content for simple identification.

Computer technological know-how researchers, pros and machine technology scholars will locate this an incomparable source and a very good start line for a extra accomplished exam of telephone biology.

"This concise e-book is a wonderful advent for desktop scientists to the interesting revolution lower than manner in molecular biology. It presents lucid, high-level descriptions of the elemental molecular mechanisms of existence, and discusses the computational ideas concerned. I want this little gem was once on hand whilst i used to be ‘learning the ropes’– it will were my first collection of examining material."

--Roni Rosenfeld, Carnegie Mellon University

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Extra info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land

Sample text

This makes it possible to see very small objects indeed. Figure 25 shows electron microscope images of a number of very small objects. Electron microscopes have some disadvantages, however. Electrons, unlike light, do not penetrate very far into a cell. Hence, if one wishes to visualize objects deep inside a cell, it is necessary to cut it into thin sections—which in turn requires extensive preparation, usually including dehydrating the cell and then allowing resin to permeate into it, or freezing the cell very rapidly.

This means that one can easily use affinity chromatography to purify mRNA from a whole cell extract. A microarray is an array of thousands Both DNA and RNA can be of locations, each of which contains either single-stranded, or DNA for a different gene. Thanks to the double-stranded. In double magic of gene sequencing, VLSI-scale stranded DNA/RNA, each is complementary to engineering, and robotics, a microarray strand the other. In the right that holds DNA for every one of the conditions and at the right thousands of genes in yeast can be made temperature, two single and mass-produced fairly inexpensively, strands that are and is about the size of a microscope complementary can spontaneously form a slide.

How a DIC microscope works. 40 A Computer Scientist’s Guide to Cell Biology Another way to obtain better images is with a fluorescent dye. Fluorescent molecules are molecules that absorb light of one frequency f, and very shortly after, emit light of another frequency g. This happens because when the atom absorbs light, an electron orbiting the nucleus of some atom in the molecule is pushed into a higher orbital—an orbit which is highly unstable. This unstable orbit typically lasts for a nanosecond or so, and when the electron returns to the lower, stable orbital, a photon is emitted.

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