By Morris J., Lycett J.

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Extra info for A Monograph of the Mollusca from the Great Oolite, Chiefly from Minchinhampton and the Coast of Yorkshire, Part I: Univalves

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1993) Overview of chemokines. Adv. Exp. Med. BioI. 351, 183-186. 3. , and Baggiolini, M. (1996) Monocyte Chemotactic Protein 4 (MCP-4), a novel structural and functional analogue ofMCP-3 and eotaxin. J. Exp. Med. 183, 2379-2384. 4. -G. (1996) HCC-1, a novel chemokine from human plasma. J. Exp. Med. 183,295-299. 5. , and Nomiyama, H. (1997) Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.

This has been subsequently confirmed using calcium-mobilization assays and in vivo leukocyte recruitment assays, and extended to demonstrate that both the CD4+and CD8+ T lymphocyte subsets respond to MIP-4 (36a). The highly restricted pattern of expression ofMIP-4, and the fact that it appears to specifically attract naive CD4+ and CD8+ T lymphocytes suggests that this chemokine may play a critical role in antigen presentation to T cells during immune priming. Further insights into the biological role of this chemokine should be gained when a receptor for MIP-4 is identified.

Murphy, P. , and Berger, E. A (1996) CC CKR5: ARANTES, MIP-1a, MIP-1~ receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272,1955-1958. 75. , Ponath, P. , Mackay, C. , and Sodroski, J. (1996) The ~-chemokine receptors CCR3 and CCR5 facilitate infection by primary HlV-l isolates. Cell 85, 1135-1148. 76. Doranz, B. , Smyth, R. , Peiper, S. , Collman, R. , and Doms, R. W. (1996) A dual-tropic primary HlV-l isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.

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