By David M. Panchision (auth.), Donald G. Phinney (eds.)
This is complete evaluate of a necessary zone of clinical enquiry, which covers a extensive spectrum of concerns. With contributions from many of the key researchers within the box, grownup Stem Cells: Biology and strategies of research deals readers a old standpoint in addition to specific insights into state of the art concepts. the quantity contextualizes the hot discovery of stem/progenitor cellphone populations resident in lots of grownup tissues and organs. It confronts the complexities scientists face in attempting to validate those cells, whereas it additionally describes and seriously evaluates the tools at the moment used to evaluate stem mobilephone self-renewal. The chapters additionally search to tell apart this approach from different facets of phone survival, akin to the legislation of existence span, senescence, and immortalization at a molecular point.
The monograph starts off with a bit that research the fundamental biology of grownup stem cells, together with chapters at the rising function of microRNAs in regulating their destiny and the molecular mechanisms that govern their self-renewal, the publication strikes directly to examine the various methodologies hired in characterizing those elusive components of our genetic makeup. the second one part information in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem mobilephone paradigm, and considers the functionality of ABC transporters and aldehyde dehydrogenase in grownup stem-cell biology. the ultimate part shifts the focal point to the life-span law and immortalization and contours a bankruptcy at the melanoma stem cellphone paradigm.
This is an authoritative quantity on one of many frontiers of genetic examine, and may function a priceless source, not only for verified scientists but in addition for these now getting into the sphere of stem telephone biology.
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Additional info for Adult Stem Cells: Biology and Methods of Analysis
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2009). However, a separate clonal analysis of Sox2-GFP reporter cells in the adult hippocampal SGZ clearly indicated that Sox2 expressing cells are extensively self-renewing and multipotent (Suh et al. 2007). This suggests that Sox2 positively regulates the NSC program throughout the lifespan. Hypoxia-inducible factor (HIF)-1a is a transcription factor that regulates a broad set of genes involved in metabolism and cell fate. HIF-1a is rapidly degraded at high oxygen tensions and is most active in low physiological oxygen tensions.
Cell Stem Cell 1:515–528. Sun Y, Goderie SK, Temple S (2005) Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells. Neuron 45:873–886. Surani MA, Durcova-Hills G, Hajkova P et al (2008) Germ line, stem cells, and epigenetic reprogramming. Cold Spring Harb Symp Quant Biol 73:9–15. Uchida N, Buck DW, He D et al (2000) Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 97:14720–14725. Vandenbosch R, Borgs L, Beukelaers P et al (2007) CDK2 is dispensable for adult hippocampal neurogenesis.