By Emil J Freireich M.D., D.Sc. (Hon.) (auth.), Laurence Baker, Frederick Valeriote, Voravit Ratanatharathorn (eds.)

This 12 months notes significant alterations within the annual Detroit melanoma Symposium. the 1st is our goal of choosing most sensible­ ics of vast curiosity to the melanoma group and studying the topic from either a simple laboratory and medical perspective. during this manner, the significance of either parts of melanoma learn are famous and the interaction among them emphasised. extra, we think that Symposia similar to this act to stimulate the elemental scientist and clinician to proceed their reports with the recognize­ ledge of the effect that every has upon the opposite and the nec­ essary cooperation required to resolve the melanoma challenge. the second one swap is the ebook of this Symposium. The pre­ vious 16 weren't devoted to manuscript shape. Given the switch in layout and reason of the sequence, we think that this and next volumes will make very important contributions to the melanoma literature. the subject of "Biology and treatment of Acute Leukemia" used to be selected for the 1st Symposium as a result of its old signif­ icance in melanoma chemotherapy. The healing purpose for human leukemia is the results of realizing the elemental tumor biology principally derived from transplantable leukemias in exper­ imental animals. it's via those types, as mentioned by means of Dr. Fred Valeriote, that we realized the mobile kinetics of leukemia, the antileukemic results of latest brokers and the ef­ fect of development perturbation through a number of chemotherapeutic brokers and their combinations.

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Biology and Therapy of Acute Leukemia: Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan — April 12–13, 1984

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Extra info for Biology and Therapy of Acute Leukemia: Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan — April 12–13, 1984

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Goldin A, Venditti JM, Humphreys SR, Dennis D, Mantel N, Greenhouse, SW: Factors influencing the specificity of action of an antileukemic agent (aminopterin). Multiple treatment schedules plus delayed administration of citovorum factor. Cancer Res. 15:57-61, 1955. Santelli G, Valeriote F: In vivo enhancement of 5fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice. J. Natl. Cancer Inst. 61:843-847, 1978. Santelli G, Valeriote F: In vivo potentiation of 5fluorouracil cytotoxicity against AKR leukemia by purines, pyrimidines and their nucleosides and deoxynucleosides.

G1ascow G, Beetham KL, Mill WB: Dose rate effects on the survival of normal hematopoietic stem cells of BALB/C mice. Int1. J. Rad. Onco1. Bio1. Phys. 9:557-563, 1983. Lorenz E, Uphoff D, Reid TR, Skelton E: Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J. Nat1. Cancer Inst. 12:197-201, 1951. Thomas ED, Storb R, Clift RA et a1: Bone marrow transplantation. New Eng. J. Med. 292:832-843, 1975. Mathe G: lmmunotherapie active de 1a L1ucemie L1210 applique apres 1a greffe tumora1e.

Principles and Practice of Oncology. B. Lippincott, Philadelphia, 1982, pp. 1402-1426, Dexter TM: Stromal cell associated hemopoiesis. J. Cell Physio1. Supp. 1:87-94, 1982. G1ascow G, Beetham KL, Mill WB: Dose rate effects on the survival of normal hematopoietic stem cells of BALB/C mice. Int1. J. Rad. Onco1. Bio1. Phys. 9:557-563, 1983. Lorenz E, Uphoff D, Reid TR, Skelton E: Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J. Nat1. Cancer Inst. 12:197-201, 1951.

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